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eBook details
- Title: Investigation Into the Origin and Tumoral Mass Correlation of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma (Technical Briefs)
- Author : Clinical Chemistry
- Release Date : January 01, 2005
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 210 KB
Description
Despite the increasing number of clinical applications of circulating Epstein-Barr virus (EBV) DNA analysis for the detection (1, 2), monitoring (3, 4), and prognostication (5, 6) of nasopharyngeal carcinoma (NPC), several fundamental questions concerning plasma EBV DNA, including its tissue origin and relationship with tumor mass, remain unanswered. In the first part of this study, we investigated the relative contributions of tumor cells and other latently EBV-infected lymphoid tissues to the pool of circulating EBV DNA. Previous studies have shown that different EBV genotypes are harbored by latently EBV-infected lymphoid tissues and blood cells (7-10) in healthy persons and patients with malignancies. On the other hand, it is well established that the EBV is monoclonal in NPC tumor tissues and other EBV-associated cancers (11-14). Therefore, investigation of the genotype of plasma EBV DNA should reveal the relative contributions of tumor cells and other latently EBV-infected lymphoid tissues to the pool of circulating EBV DNA in NPC patients.
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